All the genes identified to date, have a major effect on the regulation of appetite. For this reason, we have developed a major programme of research that focuses on eating behaviour.
We have established a number of novel methods for the study of macronutrients on satiety, food preference and for the study of the motivational drive to eat. We work closely with Professor Paul Fletcher in Cambridge undertaking studies involving functional MRI scans to look at how the brain responds to food and to drugs that might be used to treat obesity. These studies are undertaken in patients in whom we find genetic variants and in normal weight and overweight volunteers (Help us with our research).