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Oct 2017 Our autumn newsletter is out now. Find it on our Newsletters page, or subscribe to have it sent to you by email.


Oct 2017 In our recent article published in the Journal of Clinical Endocrinology and Metabolism, we used metabolomics to characterise the response to acute caloric restriction in unprecedented detail.



Help us with our Research


You can help us in a number of ways.

You may already be involved in the GOOS study and we will communicate with you through your Doctor about our research findings.

If you have been told that you have a genetic problem that is likely to be the cause of your weight problem and would like to know if there is more research going on into your gene, then please register your interest.

If you are interested in our work and would like to volunteer to take part in one of our studies, please contact usWe are looking for volunteers of all age groups and sizes (including children), so please do let your family and friends know about our research. 


What Are We Doing Now?


Biomarker Discovery


As well as measuring hormones that circulate in the blood, it is also very useful to measure something that we call biomarkers. A biomarker or biological marker can be measured in various bodily fluids such as blood and urine and can act as an indicator of normal and indeed abnormal biological processes. When we discover new potential biomarkers, they need to be rigorously tested before we can figure out if they are useful.


We often want to measure and evaluate biomarkers in our patients with specific genetic conditions that affect their weight, but for any measurement to have any relevance, we need to measure the same thing in people who do not have the condition. This is why we are now looking to recruit some volunteers to help us collect some biological samples for such testing.


For this study we are looking in the first instance for a rather specific group of people. You would need to be male, 20 to 30 years of age and not overweight. It is also important that you do not smoke and do not exercise excessively.


This study involves an overnight stay with regular blood samples being taken in the morning via something called a cannula (so only one needle!)


Why Do We Find Certain Foods More Appetising?


We are looking for children who could come in for some short tests to look at the types of food they prefer. Some of these tests involve using a computer to score pictures of food before and after a regular meal.