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Jul 2017 A new paper has been published, following our study which shows that the hormone oxytocin modulates how our brain responds to food pictures.

 

Jul 2017 In a study just published in the journal Scientific Reports we looked at a large number of genes in over 4000 children with severe obesity from the GOOS cohort.

 

Mar 2016

Stem Cell Research

 

One of the challenges when studying genes that cause weight problems has been to find a way to unravel their function by using research in the laboratory. This can often involve working with cells that behave in a way that mirrors or models how real cells work in the body. Stem cells have the ability to grow into different types of cells (heart, kidney, brain cells) in the laboratory and so can be used to study and perhaps in the future, to treat, a variety of medical conditions.

 

 

Dr Florian Merkle is a new Group Leader who has recently joined the Institute from Harvard University in the USA where he has been working on stem cells. He has found a way to take stem cells, usually made from a person's skin, and make them into neurons (nerve cells) that work in the hypothalamus, a key part of the brain involved in controlling weight. His team are going to be working with Professor Farooqi's team to test how well these neurons look and behave like the neurons in a real person. They will then work on some of the genes that cause weight problems to investigate how they might affect how neurons respond to hormones like leptin and why they might not work effectively in some people. This is a new exciting collaboration which we hope to develop further in the future.